Selected Publications

Cells Sense Curvature!

Title: Collective curvature sensing and fluidity in three-dimensional multicellular systems

Authors: Wenhui Tang, Amit Das, Adrian F. Pegoraro, Yu Long Han, Jessie Huang, David A. Roberts, Haiqian Yang, Jeffrey J. Fredberg, Darrell N. Kotton, Dapeng Bi, Ming Guo*

Nature Physics 18, pages1371–1378 (2022)

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Transfecting Cells by Mechanical Stimulus

Title: Bulk Electroporation for Intracellular Delivery Directly Driven by Mechanical Stimulus

Authors: Fan Liu*, Ze Yang, Rui Yao, Hui Li, Jia Cheng, Ming Guo*

ACS nano 16, 11, 19363–19372 (2022)

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Compression induces Gene Expression Noise

Title: Volumetric compression develops noise-driven single cell heterogeneity

Authors: Xing Zhao, Jiliang Hu, Yiwei Li*, Ming Guo*

PNAS 118 (51) e2110550118 (2021)

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Review: Cell Mechanics in Translational Medicine

Title: Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine

Authors: Yiwei Li, Ian Y Wong, Ming Guo

Small (2022)

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Order parameters for Multicellular Living Sytstems

Title: Configurational fingerprints of multicellular living systems

Authors: Haiqian Yang, Adrian Pegoraro, Yulong Han, Wenhui Tang, Rohan Abeyaratne, Max Bi, Ming Guo*

PNAS 118(44) e2109168118 (2021)

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Medium Amplitude Oscillatory Shear Microrheology (uMAOS)

Title: Optical tweezer measurements of asymptotic nonlinearities in complex fluids

Authors: Satish Gupta, Kyle Lennon, Mary Joens, Hari Bandi, Martijn Van Galen, YuLong Han, Wenhui Tang, Yiwei Li, Steven Wasserman, James Swan, Ming Guo*

Phys. Rev. E 104, 064604 (2021)

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Cell mechanics regulates cancer immunotherapy

Title: Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Authors: Kewen Lei, Armand Kurum, Murat Kaynak, Lucia Bonati, Yulong Han, Veronika Cencen, Min Gao, Yu-Qing Xie, Yugang Guo, Mélanie Hannebelle, Yangping Wu, Guanyu Zhou, Ming Guo, Georg Fantner, Mahmut Sakar, Li Tang

Nature Biomedical Engineering 5, 1411–1425 (2021)

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Review: Understanding cells as materials

Title: The cell as matter: Connecting molecular biology to cellular functions

Authors: Yiwei Li, Wenhui Tang, Ming Guo*

Matter 6(4) 1863-1891 (2021)

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Mechanics of Basement membrane

blue cell nuclei and green basement memb

Title: Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation

Authors: Hui Li, Yue Zheng, Yu Long Han, Shengqiang Cai, Ming Guo*

PNAS 118 (11) e2022422118 (2021)

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Review: Engineering methods for studying mechanics and function of Epithelial-to-Mesenchymal Transition

Title: The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems

Authors: Susan E Leggett, Alex M Hruska, Ming Guo, Ian Y Wong

Cell Communication and Signaling 119 (1) 1-24 (2021)

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Compression induced Dedifferentiated Adipocytes (CiDAs)

Title: Generation of the compression-induced dedifferentiated adipocytes (CiDAs) using hypertonic medium

Authors: Yiwei Li, Angelo S. Mao, Bo Ri Seo, Xing Zhao, Satish Kumar Gupta, Maorong Chen, Yu Long Han, Ting-Yu Shih, David J. Mooney, Ming Guo*

Bio-protocol 11(4) e3920-e3920 (2021)

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Covid-19 & Nanotechnology

Title: Insights from nanotechnology in COVID-19 treatment

Authors: Zhongmin Tang, Xingcai Zhang, Yiqing Shu, Ming Guo, Han Zhang, Wei Tao

Nanotoday 36, 101019 (2021)

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Molecular crowding impacts Wnt signaling

Title: Volumetric compression induces intracellular crowding to control intestinal organoid growth via Wnt/β-catenin signaling

Authors: Yiwei Li, Maorong Chen, Jiliang Hu, Ren Sheng, Qirong Lin, Xi He, Ming Guo*

Cell Stem Cell 28 (1), 63-78 (2021)

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Review: Fluid mechanics in Multicellular Living Systems

Title: In Pursuit of Designing Multicellular Engineered Living Systems: A Fluid Mechanical Perspective

Authors: Jean Carlos Serrano, Satish Kumar Gupta, Roger D Kamm, Ming Guo*

Annual Review of Fluid Mechanics 53, 411-437 (2021)

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Volume variation and fluid transport in cell spheroids

Title: Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids

Authors: Eoin McEvoy, Yu Long Han, Ming Guo, Vivek B Shenoy

Nature Communications 11 (1), 1-11 (2020)

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Tumor immunology

Title: Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged nanobullets

Authors: Zhe Yang, Di Gao, Xiaoqing Guo, Lin Jin, Juanjuan Zheng, Ying Wang, Shuojia Chen, Xuewei Zheng, Li Zeng, Ming Guo, Xingcai Zhang, Zhongmin Tian

ACS nano 14 (12), 17442-17457 (2020)

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Compression induced Dedifferentiated Adipocytes (CiDAs)

Title: Compression-induced dedifferentiation of adipocytes promotes tumor progression

Authors: Yiwei Li, Angelo S Mao, Bo Ri Seo, Xing Zhao, Satish Kumar Gupta, Maorong Chen, Yu Long Han, Ting-Yu Shih, David J Mooney, Ming Guo*

Science advances 6 (4), eaax5611 (2020)

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4D single cell mechanical imaging during cancer invasion

Title: Cell swelling, softening and invasion in a three-dimensional breast cancer model

Authors: Yu Long Han, Adrian F Pegoraro, Hui Li, Kaifu Li, Yuan Yuan, Guoqiang Xu, Zichen Gu, Jiawei Sun, Yukun Hao, Satish Kumar Gupta, Yiwei Li, Wenhui Tang, Hua Kang, Lianghong Teng, Jeffrey J Fredberg, Ming Guo*

Nature physics 16 (1), 101-108 (2020)

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Chapter: Optical Tweezers for cell mechanics

Title: Quantification of Cell-Matrix Interaction in 3D Using Optical Tweezers

Authors: Satish Kumar Gupta, Jiawei Sun, Yu Long Han, Chenglin Lyu, Tianlei He, Ming Guo*

Multi-scale Extracellular Matrix Mechanics and Mechanobiology 283-310 (2020)

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Intermediate filaments determine nonlinear cell mechanics

Title: High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

Authors: Jiliang Hu, Yiwei Li, Yukun Hao, Tianqi Zheng, Satish K Gupta, German Alberto Parada, Huayin Wu, Shaoting Lin, Shida Wang, Xuanhe Zhao, Robert D Goldman, Shengqiang Cai, Ming Guo*

PNAS 116 (35), 17175-17180 (2019)

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Highly stretchable engineered microtissue

Title: Helical nanofiber yarn enabling highly stretchable engineered microtissue

Authors: Yiwei Li, Fengyun Guo, Yukun Hao, Satish Kumar Gupta, Jiliang Hu, Yaqiong Wang, Nü Wang, Yong Zhao, Ming Guo*

PNAS 116 (19), 9245-9250 (2019)

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Lobster belly membrane is a ultra-tough hydrogel

Title: Natural hydrogel in American lobster: A soft armor with high toughness and strength

Authors: Jinrong Wu, Zhao Qin, Liangliang Qu, Hao Zhang, Fei Deng, Ming Guo*

Acta biomaterialia 88, 102-110 (2019)

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Anisotropic cell mechanics

Title: Anisotropic mechanics and dynamics of a living mammalian cytoplasm

Authors: Satish Kumar Gupta, Yiwei Li, Ming Guo*

Soft Matter 15 (2), 190-199 (2019)

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Fracture mechanics of cell division

Title: Fracture mechanics modeling of popping event during daughter cell separation

Authors: Yuxuan Jiang, Xudong Liang, Ming Guo, Yanping Cao, Shengqiang Cai

Biomechanics and modeling in mechanobiology 17 (4), 1131-1137 (2018)

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Cell contraction triggers nonlinear ECM stiffening

Nonlinear stress inference Microscopy of

Title: Cell contraction induces long-ranged stress stiffening in the extracellular matrix

Authors: Yu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Roger D Kamm, Martin Lenz, Chase P Broedersz, Ming Guo*

PNAS 115 (16), 4075-4080 (2018)

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Cell volume impacts cell biology

cell mechanics depends on cell volume.jp

Title: Cell volume change through water efflux impacts cell stiffness and stem cell fate

Authors: Ming Guo, Adrian F Pegoraro, Angelo Mao, Enhua H Zhou, Praveen R Arany, Yulong Han, Dylan T Burnette, Mikkel H Jensen, Karen E Kasza, Jeffrey R Moore, Frederick C Mackintosh, Jeffrey J Fredberg, David J Mooney, Jennifer Lippincott-Schwartz, David A Weitz

PNAS 114 (41), E8618-E8627 (2017)

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Compare active and passive microrheology in cells

Title: Equilibrium and out-of-equilibrium mechanics of living mammalian cytoplasm

Authors: Satish Kumar Gupta, Ming Guo*

Journal of the Mechanics and Physics of Solids 107, 284-293 (2017)

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State diagram of living cell cytoplasm

mechanical state diagram of mammalian cy

Title: Size-and speed-dependent mechanical behavior in living mammalian cytoplasm

Authors: Jiliang Hu, Somaye Jafari, Yulong Han, Alan J Grodzinsky, Shengqiang Cai, Ming Guo*

PNAS 114 (36), 9529-9534 (2017)

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Rapid circuit assembly via coffee ring effect

Title: Rapid assembly of large scale transparent circuit arrays using PDMS nanofilm shaped coffee ring

Authors: Yiwei Li, Weixia Zhang, Jiliang Hu, Yachao Wang, Xiaojun Feng, Wei Du, Ming Guo, Bi‐Feng Liu

Advanced Functional Materials 27 (11), 1606045 (2017)

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Chapter: functions of vimentin intermediate filaments

Title: Methods for determining the cellular functions of vimentin intermediate filaments

Authors: Karen M Ridge, Dale Shumaker, Amélie Robert, Caroline Hookway, Vladimir I Gelfand, Paul A Janmey, Jason Lowery, Ming Guo, David A Weitz, Edward Kuczmarski, Robert D Goldman

Methods in enzymology 568, 389-426 (2016)

Link to paper

Prior to MIT (<2015)

~~Activity-driven fluctuations in living cells.~~

É Fodor#, M Guo#, NS Gov, P Visco, DA Weitz, F van Wijland

EPL (Europhysics Letters) 110 (4), 48005 (2015)

~~Alpha-actinin binding kinetics modulate cellular dynamics and force generation~~

AJ Ehrlicher, R Krishnan, M Guo, CM Bidan, DA Weitz, MR Pollak

Proceedings of the National Academy of Sciences 112 (21), 6619-6624 (2015)

~~Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy~~

Ming Guo, Allen J Ehrlicher, Mikkel H Jensen, Malte Renz, Jeffrey R Moore, Robert D Goldman, Jennifer Lippincott-Schwartz, Frederick C Mackintosh, David A Weitz

Cell 158 (4), 822-832 (2014)

~~Identifying directional persistence in intracellular particle motion using Hidden Markov Models~~

M Röding, M Guo, DA Weitz, M Rudemo, A Särkkä

Mathematical biosciences 248, 140-145 (2014)

~~Thermally switched release from nanoparticle colloidosomes~~

S Zhou, J Fan, SS Datta, M Guo, X Guo, DA Weitz

Advanced Functional Materials 23 (47), 5925-5929 (2013)

~~The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics~~

Ming Guo, Allen J Ehrlicher, Saleemulla Mahammad, Hilary Fabich, Mikkel H Jensen, Jeffrey R Moore, Jeffrey J Fredberg, Robert D Goldman, David A Weitz

Biophysical journal 105 (7), 1562-1568 (2013)

~~Reactions in double emulsions by flow-controlled coalescence of encapsulated drops~~

Haosheng Chen, Yuanjin Zhao, Jiang Li, Ming Guo, Jiandi Wan, David A Weitz, Howard A Stone

Lab on a Chip 11 (14), 2312-2315 (2011)

~~Changes in leaf photosynthetic characteristics and water use efficiency along with tree height of 4 tree species~~

C He, J Li, M Guo, Y Wu, C Chen

Acta Ecologica Sinica 28 (7), 3008-3016 (2008)

~~Changes of Leaf Morphological, Anatomical Structure and Carbon Isotope Ratio with the Height of the Wangtian Tree (Parashorea chinensis) in Xishuangbanna, China~~

CX He, JY Li, P Zhou, M Guo, QS Zheng

Journal of integrative plant biology 50 (2), 168-173 (2008)

~~Meniscus-climbing behavior and its minimum free-energy mechanism~~

Y Yu, M Guo, X Li, QS Zheng

Langmuir 23 (21), 10546-10550 (2007)

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