Selected Publications

blue cell nuclei and green basement memb

Mechanics of Basement membrane

Title: Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation

Authors: Hui Li, Yue Zheng, Yu Long Han, Shengqiang Cai, Ming Guo*

PNAS 118 (11) e2022422118 (2021)

Link to paper

Review: Engineering methods for studying mechanics and function of Epithelial-to-Mesenchymal Transition

Title: The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems

Authors: Susan E Leggett, Alex M Hruska, Ming Guo, Ian Y Wong

Cell Communication and Signaling 119 (1) 1-24 (2021)

Link to paper

Compression induced Dedifferentiated Adipocytes (CiDAs)

Title: Generation of the compression-induced dedifferentiated adipocytes (CiDAs) using hypertonic medium

Authors: Yiwei Li, Angelo S. Mao, Bo Ri Seo, Xing Zhao, Satish Kumar Gupta, Maorong Chen, Yu Long Han, Ting-Yu Shih, David J. Mooney, Ming Guo*

Bio-protocol 11(4) e3920-e3920 (2021)

Link to paper

Covid-19 & Nanotechnology

Title: Insights from nanotechnology in COVID-19 treatment

Authors: Zhongmin Tang, Xingcai Zhang, Yiqing Shu, Ming Guo, Han Zhang, Wei Tao

Nanotoday 36, 101019 (2021)

Link to paper

Molecular crowding impacts Wnt signaling

Title: Volumetric compression induces intracellular crowding to control intestinal organoid growth via Wnt/β-catenin signaling

Authors: Yiwei Li, Maorong Chen, Jiliang Hu, Ren Sheng, Qirong Lin, Xi He, Ming Guo*

Cell Stem Cell 28 (1), 63-78 (2021)

Link to paper

Review: Fluid mechanics in Multicellular Living Systems

Title: In Pursuit of Designing Multicellular Engineered Living Systems: A Fluid Mechanical Perspective

Authors: Jean Carlos Serrano, Satish Kumar Gupta, Roger D Kamm, Ming Guo*

Annual Review of Fluid Mechanics 53, 411-437 (2021)

Link to paper

Volume variation and fluid transport in cell spheroids

Title: Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids

Authors: Eoin McEvoy, Yu Long Han, Ming Guo, Vivek B Shenoy

Nature Communications 11 (1), 1-11 (2020)

Link to paper

Tumor immunology

Title: Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged nanobullets

Authors: Zhe Yang, Di Gao, Xiaoqing Guo, Lin Jin, Juanjuan Zheng, Ying Wang, Shuojia Chen, Xuewei Zheng, Li Zeng, Ming Guo, Xingcai Zhang, Zhongmin Tian

ACS nano 14 (12), 17442-17457 (2020)

Link to paper

Compression induced Dedifferentiated Adipocytes (CiDAs)

Title: Compression-induced dedifferentiation of adipocytes promotes tumor progression

Authors: Yiwei Li, Angelo S Mao, Bo Ri Seo, Xing Zhao, Satish Kumar Gupta, Maorong Chen, Yu Long Han, Ting-Yu Shih, David J Mooney, Ming Guo*

Science advances 6 (4), eaax5611 (2020)

Link to paper

4D single cell mechanical imaging during cancer invasion

Title: Cell swelling, softening and invasion in a three-dimensional breast cancer model

Authors: Yu Long Han, Adrian F Pegoraro, Hui Li, Kaifu Li, Yuan Yuan, Guoqiang Xu, Zichen Gu, Jiawei Sun, Yukun Hao, Satish Kumar Gupta, Yiwei Li, Wenhui Tang, Hua Kang, Lianghong Teng, Jeffrey J Fredberg, Ming Guo*

Nature physics 16 (1), 101-108 (2020)

Link to paper

Chapter: Optical Tweezers for cell mechanics

Title: Quantification of Cell-Matrix Interaction in 3D Using Optical Tweezers

Authors: Satish Kumar Gupta, Jiawei Sun, Yu Long Han, Chenglin Lyu, Tianlei He, Ming Guo*

Multi-scale Extracellular Matrix Mechanics and Mechanobiology 283-310 (2020)

Link to paper

Intermediate filaments determine nonlinear cell mechanics

Title: High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

Authors: Jiliang Hu, Yiwei Li, Yukun Hao, Tianqi Zheng, Satish K Gupta, German Alberto Parada, Huayin Wu, Shaoting Lin, Shida Wang, Xuanhe Zhao, Robert D Goldman, Shengqiang Cai, Ming Guo*

PNAS 116 (35), 17175-17180 (2019)

Link to paper

Highly stretchable engineered microtissue

Title: Helical nanofiber yarn enabling highly stretchable engineered microtissue

Authors: Yiwei Li, Fengyun Guo, Yukun Hao, Satish Kumar Gupta, Jiliang Hu, Yaqiong Wang, Nü Wang, Yong Zhao, Ming Guo*

PNAS 116 (19), 9245-9250 (2019)

Link to paper

Lobster belly membrane is a ultra-tough hydrogel

Title: Natural hydrogel in American lobster: A soft armor with high toughness and strength

Authors: Jinrong Wu, Zhao Qin, Liangliang Qu, Hao Zhang, Fei Deng, Ming Guo*

Acta biomaterialia 88, 102-110 (2019)

Link to paper

Anisotropic cell mechanics

Title: Anisotropic mechanics and dynamics of a living mammalian cytoplasm

Authors: Satish Kumar Gupta, Yiwei Li, Ming Guo*

Soft Matter 15 (2), 190-199 (2019)

Link to paper

Fracture mechanics of cell division

Title: Fracture mechanics modeling of popping event during daughter cell separation

Authors: Yuxuan Jiang, Xudong Liang, Ming Guo, Yanping Cao, Shengqiang Cai

Biomechanics and modeling in mechanobiology 17 (4), 1131-1137 (2018)

Link to paper

Nonlinear stress inference Microscopy of

Cell contraction triggers nonlinear ECM stiffening

Title: Cell contraction induces long-ranged stress stiffening in the extracellular matrix

Authors: Yu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Roger D Kamm, Martin Lenz, Chase P Broedersz, Ming Guo*

PNAS 115 (16), 4075-4080 (2018)

Link to paper

cell mechanics depends on cell volume.jp

Cell volume impacts cell biology

Title: Cell volume change through water efflux impacts cell stiffness and stem cell fate

Authors: Ming Guo, Adrian F Pegoraro, Angelo Mao, Enhua H Zhou, Praveen R Arany, Yulong Han, Dylan T Burnette, Mikkel H Jensen, Karen E Kasza, Jeffrey R Moore, Frederick C Mackintosh, Jeffrey J Fredberg, David J Mooney, Jennifer Lippincott-Schwartz, David A Weitz

PNAS 114 (41), E8618-E8627 (2017)

Link to paper

Compare active and passive microrheology in cells

Title: Equilibrium and out-of-equilibrium mechanics of living mammalian cytoplasm

Authors: Satish Kumar Gupta, Ming Guo*

Journal of the Mechanics and Physics of Solids 107, 284-293 (2017)

Link to paper

mechanical state diagram of mammalian cy

State diagram of living cell cytoplasm

Title: Size-and speed-dependent mechanical behavior in living mammalian cytoplasm

Authors: Jiliang Hu, Somaye Jafari, Yulong Han, Alan J Grodzinsky, Shengqiang Cai, Ming Guo*

PNAS 114 (36), 9529-9534 (2017)

Link to paper

Rapid circuit assembly via coffee ring effect

Title: Rapid assembly of large scale transparent circuit arrays using PDMS nanofilm shaped coffee ring

Authors: Yiwei Li, Weixia Zhang, Jiliang Hu, Yachao Wang, Xiaojun Feng, Wei Du, Ming Guo, Bi‐Feng Liu

Advanced Functional Materials 27 (11), 1606045 (2017)

Link to paper

Chapter: functions of vimentin intermediate filaments

Title: Methods for determining the cellular functions of vimentin intermediate filaments

Authors: Karen M Ridge, Dale Shumaker, Amélie Robert, Caroline Hookway, Vladimir I Gelfand, Paul A Janmey, Jason Lowery, Ming Guo, David A Weitz, Edward Kuczmarski, Robert D Goldman

Methods in enzymology 568, 389-426 (2016)

Link to paper

Prior to MIT (<2015)

~~Activity-driven fluctuations in living cells.~~

É Fodor#, M Guo#, NS Gov, P Visco, DA Weitz, F van Wijland

EPL (Europhysics Letters) 110 (4), 48005 (2015)

~~Alpha-actinin binding kinetics modulate cellular dynamics and force generation~~

AJ Ehrlicher, R Krishnan, M Guo, CM Bidan, DA Weitz, MR Pollak

Proceedings of the National Academy of Sciences 112 (21), 6619-6624 (2015)

~~Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy~~

Ming Guo, Allen J Ehrlicher, Mikkel H Jensen, Malte Renz, Jeffrey R Moore, Robert D Goldman, Jennifer Lippincott-Schwartz, Frederick C Mackintosh, David A Weitz

Cell 158 (4), 822-832 (2014)

~~Identifying directional persistence in intracellular particle motion using Hidden Markov Models~~

M Röding, M Guo, DA Weitz, M Rudemo, A Särkkä

Mathematical biosciences 248, 140-145 (2014)

~~Thermally switched release from nanoparticle colloidosomes~~

S Zhou, J Fan, SS Datta, M Guo, X Guo, DA Weitz

Advanced Functional Materials 23 (47), 5925-5929 (2013)

~~The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics~~

Ming Guo, Allen J Ehrlicher, Saleemulla Mahammad, Hilary Fabich, Mikkel H Jensen, Jeffrey R Moore, Jeffrey J Fredberg, Robert D Goldman, David A Weitz

Biophysical journal 105 (7), 1562-1568 (2013)

~~Reactions in double emulsions by flow-controlled coalescence of encapsulated drops~~

Haosheng Chen, Yuanjin Zhao, Jiang Li, Ming Guo, Jiandi Wan, David A Weitz, Howard A Stone

Lab on a Chip 11 (14), 2312-2315 (2011)

~~Changes in leaf photosynthetic characteristics and water use efficiency along with tree height of 4 tree species~~

C He, J Li, M Guo, Y Wu, C Chen

Acta Ecologica Sinica 28 (7), 3008-3016 (2008)

~~Changes of Leaf Morphological, Anatomical Structure and Carbon Isotope Ratio with the Height of the Wangtian Tree (Parashorea chinensis) in Xishuangbanna, China~~

CX He, JY Li, P Zhou, M Guo, QS Zheng

Journal of integrative plant biology 50 (2), 168-173 (2008)

~~Meniscus-climbing behavior and its minimum free-energy mechanism~~

Y Yu, M Guo, X Li, QS Zheng

Langmuir 23 (21), 10546-10550 (2007)

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the Guo Lab

of Cell Mechanics

Selected Publications

Mechanics of Basement membrane

Review: Engineering methods for studying mechanics and function of Epithelial-to-Mesenchymal Transition

Compression induced Dedifferentiated Adipocytes (CiDAs)

Covid-19 & Nanotechnology

Molecular crowding impacts Wnt signaling

Review: Fluid mechanics in Multicellular Living Systems

Volume variation and fluid transport in cell spheroids

Tumor immunology

Compression induced Dedifferentiated Adipocytes (CiDAs)

4D single cell mechanical imaging during cancer invasion

Chapter: Optical Tweezers for cell mechanics

Intermediate filaments determine nonlinear cell mechanics

Highly stretchable engineered microtissue

Lobster belly membrane is a ultra-tough hydrogel

Anisotropic cell mechanics

Fracture mechanics of cell division

Cell contraction triggers nonlinear ECM stiffening

Cell volume impacts cell biology

Compare active and passive microrheology in cells

State diagram of living cell cytoplasm

Rapid circuit assembly via coffee ring effect

Chapter: functions of vimentin intermediate filaments

Prior to MIT (<2015)